![]() Research Interests: The synthesis of polymers and nanoparticles Research interests: synthesis of different kinds of nanoparticles with different chemical behaviours. Research interests: emulsion polymerisation Research interests: self-immolative polymers, endosomal escape. Research interests: polymer nanoparticles, fluorescent sensors. Research interests include : protein-polymer conjugates, targeting. Research interests: synthesis of stimuli responsive monomers and polymers, star polymers ![]() Research interests: stimuli-responsive nanoparticles, self-assembly, emulsion polymerisation, understanding cellular behaviour. However, it was found the molecular weight of the polymer significantly reduced the endosomal escape capabilities of the nanoparticles. The molecular weight of the polymers was found to have minimal effect on the material properties such as size and pH of disassembly. In this paper a library of pH responsive nanoparticles were synthesised using different molecular weight polymer building blocks. 2017, 9 e1452Ĭontrolling Endosomal Escape Using pH Responsive Nanoparticles This review looks at the current knowledge in this area. There are still many questions about how materials escape the endosome and how it can best be quantified. It is important that we develop strategies to release nanoparticles from these compartments as they are not the site of action for the majority of therapeutic cargo. Nanoparticle carriers are commonly internalised into cells through endocytosis and then become localised in acidic compartments called endosomes/lysosomes. This review article discusses an important bottleneck in nanoparticle delivery referred to as endosomal escape. Nanoescapology: Understanding Endosomal Escape It was further demonstrated that reducing the holo-Transferrin amount on the surface of the particles could enhance the targeting behavior of the nanoparticles. It was shown that the particles were pH responsive and this pH response could be tuned by the pKa of the polymer attached. In this paper the conjugation of holo-Transferrin to charge-shifting polymers and the self-assembly of these conjugates into nanoparticles was reported. Tuning the Behaviour of Protein-Polymer Nanoparticles Secondly, high escape was observed in nanoparticles when the pH of disassembly was high (7.2-6.8) and again when it was low (pH 4.9).ĪCS Applied Nanomaterials 2018, DOI: 10.1021/acsanm.8b00338 Two interesting findings were reported, firstly, that sufficient particle concentration was fundamental for achieving efficient endosomal escape. The cellular behaviour of this library was investigated at a range of particle concentrations. In this paper a library of nanoparticles were synthesised which disassembled at pHs ranging from 7.2 to 4.9. It was established in 2001 by Peter Gregory, the Editor of Advanced Materials, when the Wiley journal Advanced Materials for Optics and Electronics was discontinued.Īdvanced Functional Materials is the sister journal to Advanced Materials and publishes full papers and feature articles on the development and applications of functional materials, including topics in chemistry, physics, nanotechnology, ceramics, metallurgy, and biomaterials.Controlling Endosomal Escape by Tuning the pH of Disassembly Publishing formats include original research papers, feature articles and highlights. Topical coverage includes photovoltaics, organic electronics, carbon materials, nanotechnology, liquid crystals, magnetic materials, surfaces and interfaces, and biomaterials. ![]() However, it has been published under other titles since 1985.Ĭoverage of this journal encompasses all topics pertaining to materials science. Advanced Functional Materials is a bimonthly peer-reviewed scientific journal, established in February 2001, is published by Wiley-VCH. ![]()
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